Additive effects of non-invasive ventilation to hyperoxia on cerebral oxygenation in COPD patients with exercise-related O2 desaturation

Summary Background It is currently unknown whether potential haemodynamic improvements induced by non‐invasive ventilation (NIV) would positively impact upon cerebral oxygenation (COx) in patients with moderate‐to‐severe chronic obstructive pulmonary disease (COPD). Objective To investigate the effects of NIV on exercise COx in COPD patients presenting with exercise‐related O2 desaturation. Methods On a double‐blind trial, 13 males (FEV1 = 48·8 ± 15·1% predicted) were randomly assigned to NIV (16 cmH2O IPS and 5 cmH2O PEEP) plus HOx (FiO2 = 0·4) or sham NIV (7 cmH2O IPS and 5 cmH2O PEEP to overcome breathing circuit resistance) plus HOx during ramp‐incremental exercise performed on different days. Near‐infrared spectroscopy and impedance cardiography assessed changes (Δ) in COx and cardiac output (QT), respectively. Results There were no significant between‐intervention differences in peak work rate, ventilation and reported symptoms (P>0·05). Peripheral oxyhaemoglobin saturation remained above 98% throughout the tests. NIV + HOx was associated with larger increases in Δ COx, Δ QT and Δ stroke volume at maximal and submaximal exercise (P