A Hybrid De-Noising Method on LASCA Images of Blood Vessels

A denoising approach is proposed that based on the combination of wiener filtering, nonlinear filtering and wavelet fusion, which denoise the LASCA (LAser Speckle Contrast Analysis) image of blood vessels in Small Animals. The approach first performs laser spectral contrast analysis on brain blood flow in rats, get their spatial and temporal contrast images. Then, a denoising filtering method is proposed to deal with noise in LASCA. The image restoration is achieved by applying the proposed admixture filtering, and the subjective estimation and objective estimation are given to the denoising images. As our experimental results shown, the proposed method provides clearer subjective sense and improved to over 25 db for PSNR.