Comparison of Short-term Outcomes of Thrombolysis for In-Hospital Stroke and Out-of-Hospital Stroke in United States

BACKGROUND AND PURPOSE—In-hospital stroke (IHS) differs from out-of-hospital stroke (OHS) in risk factors and outcomes. We compared IHS and OHS treated with thrombolysis from a large national cohort in a cross-sectional study to further clarify these differences. METHODS—The Nationwide Inpatient Sample for the years 2005–2010 was searched for adult acute ischemic stroke cases treated with intravenous or intra-arterial thrombolysis. Patients treated on the day of admission were classified as OHS. We compared the demographic and hospital characteristics, comorbidities, and short-term outcomes of thrombolysed IHS and OHS. RESULTS—IHS included 8.7% of 11 750 thrombolysed stroke cases in this study. IHS was associated with a higher comorbidity profile and higher rates of acute medical conditions compared with OHS. IHS had higher inpatient mortality (15.7% versus 9.6%; P