Characterization of the mechanical and biological properties of a new alumina scaffold
In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute. In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold. The results obtained showed that this scaffold has high...
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| Veröffentlicht in: | Journal of applied biomaterials & functional materials 2013-01, Vol.11 (1), p.e18-25 |
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| container_title | Journal of applied biomaterials & functional materials |
| container_volume | 11 |
| creator | Batista, Patrícia S P Rodrigues, Miguel A A Silva, Daniela M R Morgado, Patrícia I C Henriques, Joaquim P Almeida, Maria O Silva, Abílio P Correia, Ilídio J |
| description | In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute.
In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold.
The results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. The in vivo studies revealed no systemic reaction.
The alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy. |
| doi_str_mv | 10.5301/JABFM.2012.9264 |
| format | Article |
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In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold.
The results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. The in vivo studies revealed no systemic reaction.
The alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy.</description><identifier>ISSN: 2280-8000</identifier><identifier>EISSN: 2280-8000</identifier><identifier>DOI: 10.5301/JABFM.2012.9264</identifier><identifier>PMID: 22798232</identifier><language>eng</language><publisher>United States</publisher><subject>Aluminum Oxide - chemistry ; Aluminum Oxide - pharmacology ; Animals ; Bone Regeneration - drug effects ; Bone Substitutes - chemical synthesis ; Bone Substitutes - chemistry ; Bone Substitutes - pharmacology ; Cells, Cultured ; Humans ; Materials Testing ; Mechanical Phenomena ; Osteoblasts - drug effects ; Osteoblasts - physiology ; Rats ; Rats, Wistar ; Tissue Engineering - methods ; Tissue Scaffolds - chemistry</subject><ispartof>Journal of applied biomaterials & functional materials, 2013-01, Vol.11 (1), p.e18-25</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c251t-beee38e8a04e028c7abd25a46a4e391f0bf8734f693696dcab9bb9d8929c91753</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22798232$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Batista, Patrícia S P</creatorcontrib><creatorcontrib>Rodrigues, Miguel A A</creatorcontrib><creatorcontrib>Silva, Daniela M R</creatorcontrib><creatorcontrib>Morgado, Patrícia I C</creatorcontrib><creatorcontrib>Henriques, Joaquim P</creatorcontrib><creatorcontrib>Almeida, Maria O</creatorcontrib><creatorcontrib>Silva, Abílio P</creatorcontrib><creatorcontrib>Correia, Ilídio J</creatorcontrib><title>Characterization of the mechanical and biological properties of a new alumina scaffold</title><title>Journal of applied biomaterials & functional materials</title><addtitle>J Appl Biomater Funct Mater</addtitle><description>In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute.
In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold.
The results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. The in vivo studies revealed no systemic reaction.
The alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy.</description><subject>Aluminum Oxide - chemistry</subject><subject>Aluminum Oxide - pharmacology</subject><subject>Animals</subject><subject>Bone Regeneration - drug effects</subject><subject>Bone Substitutes - chemical synthesis</subject><subject>Bone Substitutes - chemistry</subject><subject>Bone Substitutes - pharmacology</subject><subject>Cells, Cultured</subject><subject>Humans</subject><subject>Materials Testing</subject><subject>Mechanical Phenomena</subject><subject>Osteoblasts - drug effects</subject><subject>Osteoblasts - physiology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Tissue Engineering - methods</subject><subject>Tissue Scaffolds - chemistry</subject><issn>2280-8000</issn><issn>2280-8000</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkElPwzAQRi0Eoqj0zA35yKWtlyz2sVSURUVcgKs1dsY0KEuJEyH49SRtQZzmG-nNp9Ej5IKzWSwZnz8srlePM8G4mGmRREfkTAjFpooxdvwvj8gkhPc-MMUTHctTMhIi1UpIcUZelxtowLXY5N_Q5nVFa0_bDdIS3Qaq3EFBocqozeuiftut26beYtPmGAYWaIWfFIquzCugwYH3dZGdkxMPRcDJYY7Jy-rmeXk3XT_d3i8X66kTMW-nFhGlQgUsQiaUS8FmIoYogQil5p5Zr1IZ-UTLRCeZA6ut1ZnSQjvN01iOydW-t3_qo8PQmjIPDosCKqy7YLhMBUuVEFGPzveoa-oQGvRm2-QlNF-GMzP4NDufZvBpBp_9xeWhvLMlZn_8rz35A09rcMk</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Batista, Patrícia S P</creator><creator>Rodrigues, Miguel A A</creator><creator>Silva, Daniela M R</creator><creator>Morgado, Patrícia I C</creator><creator>Henriques, Joaquim P</creator><creator>Almeida, Maria O</creator><creator>Silva, Abílio P</creator><creator>Correia, Ilídio J</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Characterization of the mechanical and biological properties of a new alumina scaffold</title><author>Batista, Patrícia S P ; Rodrigues, Miguel A A ; Silva, Daniela M R ; Morgado, Patrícia I C ; Henriques, Joaquim P ; Almeida, Maria O ; Silva, Abílio P ; Correia, Ilídio J</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c251t-beee38e8a04e028c7abd25a46a4e391f0bf8734f693696dcab9bb9d8929c91753</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aluminum Oxide - chemistry</topic><topic>Aluminum Oxide - pharmacology</topic><topic>Animals</topic><topic>Bone Regeneration - drug effects</topic><topic>Bone Substitutes - chemical synthesis</topic><topic>Bone Substitutes - chemistry</topic><topic>Bone Substitutes - pharmacology</topic><topic>Cells, Cultured</topic><topic>Humans</topic><topic>Materials Testing</topic><topic>Mechanical Phenomena</topic><topic>Osteoblasts - drug effects</topic><topic>Osteoblasts - physiology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Tissue Engineering - methods</topic><topic>Tissue Scaffolds - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Batista, Patrícia S P</creatorcontrib><creatorcontrib>Rodrigues, Miguel A A</creatorcontrib><creatorcontrib>Silva, Daniela M R</creatorcontrib><creatorcontrib>Morgado, Patrícia I C</creatorcontrib><creatorcontrib>Henriques, Joaquim P</creatorcontrib><creatorcontrib>Almeida, Maria O</creatorcontrib><creatorcontrib>Silva, Abílio P</creatorcontrib><creatorcontrib>Correia, Ilídio J</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of applied biomaterials & functional materials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Batista, Patrícia S P</au><au>Rodrigues, Miguel A A</au><au>Silva, Daniela M R</au><au>Morgado, Patrícia I C</au><au>Henriques, Joaquim P</au><au>Almeida, Maria O</au><au>Silva, Abílio P</au><au>Correia, Ilídio J</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characterization of the mechanical and biological properties of a new alumina scaffold</atitle><jtitle>Journal of applied biomaterials & functional materials</jtitle><addtitle>J Appl Biomater Funct Mater</addtitle><date>2013-01-01</date><risdate>2013</risdate><volume>11</volume><issue>1</issue><spage>e18</spage><epage>25</epage><pages>e18-25</pages><issn>2280-8000</issn><eissn>2280-8000</eissn><abstract>In this work, an alumina scaffold was produced through a new method to be used in a near future as a bone substitute.
In vitro and in vivo studies were performed in order to characterize the mechanical and biological properties of the scaffold.
The results obtained showed that this scaffold has high mechanical resistance and a porous surface that allows human osteoblast cells to adhere and proliferate. The in vivo studies revealed no systemic reaction.
The alumina scaffold produced herein has the mechanical and biological properties that are compatible with its application in bone therapy.</abstract><cop>United States</cop><pmid>22798232</pmid><doi>10.5301/JABFM.2012.9264</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of applied biomaterials & functional materials, 2013-01, Vol.11 (1), p.e18-25 |
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| language | eng |
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| source | MEDLINE; Sage Journals GOLD Open Access 2024; Alma/SFX Local Collection |
| subjects | Aluminum Oxide - chemistry Aluminum Oxide - pharmacology Animals Bone Regeneration - drug effects Bone Substitutes - chemical synthesis Bone Substitutes - chemistry Bone Substitutes - pharmacology Cells, Cultured Humans Materials Testing Mechanical Phenomena Osteoblasts - drug effects Osteoblasts - physiology Rats Rats, Wistar Tissue Engineering - methods Tissue Scaffolds - chemistry |
| title | Characterization of the mechanical and biological properties of a new alumina scaffold |
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