Facilitation of shock-induced fighting in the rat after DSP-4, a selective noradrenergic neurotoxin

Rats treated with DSP-4 showed a marked enhancement of shock-induced fighting (SIF). Administration of l-propranolol attenuated or completely counteracted SIF in control animals, but only the highest dose (10 mg/kg) of this β-adrenergic antagonist was effective in reducing SIF in DSP-4 animals. Othe...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1983-04, Vol.18 (4), p.625-628
Hauptverfasser:	Mogilnicka, E., Dooley, D.J., Boissard, C.G., Delini-Stula, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - pharmacology Aggression - drug effects Amines - pharmacology Animals Benzylamines - pharmacology Drug Interactions DSP-4 Electroshock Humans l-Propranolol Male Neurotoxins - pharmacology Noradrenaline depletion Norepinephrine - metabolism Oxotremorine - pharmacology Piperidines - pharmacology Propranolol - pharmacology Rats Rats, Inbred Strains Shock-induced fighting Stereotyped Behavior - drug effects
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