Facilitation of shock-induced fighting in the rat after DSP-4, a selective noradrenergic neurotoxin

Rats treated with DSP-4 showed a marked enhancement of shock-induced fighting (SIF). Administration of l-propranolol attenuated or completely counteracted SIF in control animals, but only the highest dose (10 mg/kg) of this β-adrenergic antagonist was effective in reducing SIF in DSP-4 animals. Othe...

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Veröffentlicht in:	Pharmacology, biochemistry and behavior biochemistry and behavior, 1983-04, Vol.18 (4), p.625-628
Hauptverfasser:	Mogilnicka, E., Dooley, D.J., Boissard, C.G., Delini-Stula, A.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Hydroxytryptophan - pharmacology Aggression - drug effects Amines - pharmacology Animals Benzylamines - pharmacology Drug Interactions DSP-4 Electroshock Humans l-Propranolol Male Neurotoxins - pharmacology Noradrenaline depletion Norepinephrine - metabolism Oxotremorine - pharmacology Piperidines - pharmacology Propranolol - pharmacology Rats Rats, Inbred Strains Shock-induced fighting Stereotyped Behavior - drug effects
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Zusammenfassung:	Rats treated with DSP-4 showed a marked enhancement of shock-induced fighting (SIF). Administration of l-propranolol attenuated or completely counteracted SIF in control animals, but only the highest dose (10 mg/kg) of this β-adrenergic antagonist was effective in reducing SIF in DSP-4 animals. Other behavioral experiments indicated that the responsiveness of DSP-4 rats to dopaminergic, serotoninergic, and cholinergic agonists was unchanged compared to that of control rats. The results confirm the participation of the noradrenergic system in SIF, and substantiate an involvement of β-adrenergic receptors in this kind of aggression.
ISSN:	0091-3057 1873-5177
DOI:	10.1016/0091-3057(83)90291-5