Biotransformation of 14-deoxy-14-methylenetriptolide into a novel hydroxylation product by Neurospora crassa
The biotransformation of 14-deoxy-14-methylenetriptolide by Neurospora crassa CGMCC AS 3.1604 to produce a new hydroxylation derivative was studied. The structure of this novel compound was determined using spectral data. This biotransformation using whole cells conditioned for 4 days transformed ap...
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| Veröffentlicht in: | Journal of bioscience and bioengineering 2013-08, Vol.116 (2), p.199-202 |
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| container_title | Journal of bioscience and bioengineering |
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| creator | Chen, Zhouzhou Li, Ji'an Lin, Huimin Shao, Lei Qin, Jihong Fan, Xing Dong, Xiaojing Chen, Daijie |
| description | The biotransformation of 14-deoxy-14-methylenetriptolide by Neurospora crassa CGMCC AS 3.1604 to produce a new hydroxylation derivative was studied. The structure of this novel compound was determined using spectral data. This biotransformation using whole cells conditioned for 4 days transformed approximately 65% (mol ratio) of the substrate into the compound (5R)-5-hydroxy-14-deoxy-14-methylenetriptolide. |
| doi_str_mv | 10.1016/j.jbiosc.2013.01.023 |
| format | Article |
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The structure of this novel compound was determined using spectral data. This biotransformation using whole cells conditioned for 4 days transformed approximately 65% (mol ratio) of the substrate into the compound (5R)-5-hydroxy-14-deoxy-14-methylenetriptolide.</description><identifier>ISSN: 1389-1723</identifier><identifier>EISSN: 1347-4421</identifier><identifier>DOI: 10.1016/j.jbiosc.2013.01.023</identifier><identifier>PMID: 23465510</identifier><language>eng</language><publisher>Amsterdam: Elsevier B.V</publisher><subject>(5R)-5-Hydroxy-14-deoxy-14-methylenetriptolide ; 14-Deoxy-14-methylenetriptolide ; Bioconversions. Hemisynthesis ; Biological and medical sciences ; Biotechnology ; Biotransformation ; Diterpenes - chemistry ; Diterpenes - metabolism ; Epoxy Compounds - chemistry ; Epoxy Compounds - metabolism ; Fundamental and applied biological sciences. Psychology ; Hydroxylation ; Methods. Procedures. 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The structure of this novel compound was determined using spectral data. This biotransformation using whole cells conditioned for 4 days transformed approximately 65% (mol ratio) of the substrate into the compound (5R)-5-hydroxy-14-deoxy-14-methylenetriptolide.</description><subject>(5R)-5-Hydroxy-14-deoxy-14-methylenetriptolide</subject><subject>14-Deoxy-14-methylenetriptolide</subject><subject>Bioconversions. Hemisynthesis</subject><subject>Biological and medical sciences</subject><subject>Biotechnology</subject><subject>Biotransformation</subject><subject>Diterpenes - chemistry</subject><subject>Diterpenes - metabolism</subject><subject>Epoxy Compounds - chemistry</subject><subject>Epoxy Compounds - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hydroxylation</subject><subject>Methods. Procedures. 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| fulltext | fulltext |
| identifier | ISSN: 1389-1723 |
| ispartof | Journal of bioscience and bioengineering, 2013-08, Vol.116 (2), p.199-202 |
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| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | (5R)-5-Hydroxy-14-deoxy-14-methylenetriptolide 14-Deoxy-14-methylenetriptolide Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformation Diterpenes - chemistry Diterpenes - metabolism Epoxy Compounds - chemistry Epoxy Compounds - metabolism Fundamental and applied biological sciences. Psychology Hydroxylation Methods. Procedures. Technologies Neurospora crassa Neurospora crassa - metabolism Triptonide |
| title | Biotransformation of 14-deoxy-14-methylenetriptolide into a novel hydroxylation product by Neurospora crassa |
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