Biotransformation of 14-deoxy-14-methylenetriptolide into a novel hydroxylation product by Neurospora crassa

The biotransformation of 14-deoxy-14-methylenetriptolide by Neurospora crassa CGMCC AS 3.1604 to produce a new hydroxylation derivative was studied. The structure of this novel compound was determined using spectral data. This biotransformation using whole cells conditioned for 4 days transformed ap...

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Veröffentlicht in:	Journal of bioscience and bioengineering 2013-08, Vol.116 (2), p.199-202
Hauptverfasser:	Chen, Zhouzhou, Li, Ji'an, Lin, Huimin, Shao, Lei, Qin, Jihong, Fan, Xing, Dong, Xiaojing, Chen, Daijie
Format:	Artikel
Sprache:	eng
Schlagworte:	(5R)-5-Hydroxy-14-deoxy-14-methylenetriptolide 14-Deoxy-14-methylenetriptolide Bioconversions. Hemisynthesis Biological and medical sciences Biotechnology Biotransformation Diterpenes - chemistry Diterpenes - metabolism Epoxy Compounds - chemistry Epoxy Compounds - metabolism Fundamental and applied biological sciences. Psychology Hydroxylation Methods. Procedures. Technologies Neurospora crassa Neurospora crassa - metabolism Triptonide
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Zusammenfassung:	The biotransformation of 14-deoxy-14-methylenetriptolide by Neurospora crassa CGMCC AS 3.1604 to produce a new hydroxylation derivative was studied. The structure of this novel compound was determined using spectral data. This biotransformation using whole cells conditioned for 4 days transformed approximately 65% (mol ratio) of the substrate into the compound (5R)-5-hydroxy-14-deoxy-14-methylenetriptolide.
ISSN:	1389-1723 1347-4421
DOI:	10.1016/j.jbiosc.2013.01.023