Therapeutic implications of iodine-125 cytotoxicity

The biological consequences of differential subcellular radionuclide accumulation within nuclear structures have important implications for the design and development of new therapeutic agents for cancer management. A growing body of experimental data demonstrates that localization of 125I within th...

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Veröffentlicht in:	Int. J. Radiat. Oncol., Biol. Phys.; (United States) Biol. Phys.; (United States), 1982-11, Vol.8 (11), p.1903-1908
Hauptverfasser:	Bloomer, William D., McLaughlin, William H., James Adelstein, S.
Format:	Artikel
Sprache:	eng
Schlagworte:	550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-) ANIMAL CELLS Animals ANTIMETABOLITES AZINES BETA DECAY RADIOISOTOPES BIOLOGICAL EFFECTS BIOLOGICAL LOCALIZATION CELL CONSTITUENTS CELL KILLING Cell Line CELL NUCLEI Cell Survival - radiation effects CLATHRATES Cricetinae Cricetulus DAYS LIVING RADIOISOTOPES DNA DRUGS ELECTRON CAPTURE RADIOISOTOPES Estrogen receptor ESTROGENS GENETIC EFFECTS HETEROCYCLIC COMPOUNDS HORMONES Humans HYDROXY COMPOUNDS Idoxuridine - therapeutic use Intercalating agents Intercalating Agents - therapeutic use INTERMEDIATE MASS NUCLEI Internal emitters IODINE 125 IODINE ISOTOPES Iodine Radioisotopes - therapeutic use Iodine-125 toxicity IODODEOXYURIDINE IODOURACILS ISOTOPES LABELLED COMPOUNDS lododeoxyuridine Mice Neoplasms - radiotherapy NUCLEI NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ODD-EVEN NUCLEI ORGANIC COMPOUNDS ORGANIC HALOGEN COMPOUNDS ORGANIC IODINE COMPOUNDS ORGANIC NITROGEN COMPOUNDS PYRIMIDINES RADIOISOTOPES RADIOLOGY AND NUCLEAR MEDICINE RECEPTORS RIBOSIDES STEROID HORMONES TAMOXIFEN Tamoxifen - therapeutic use TUMOR CELLS URACILS
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Zusammenfassung:	The biological consequences of differential subcellular radionuclide accumulation within nuclear structures have important implications for the design and development of new therapeutic agents for cancer management. A growing body of experimental data demonstrates that localization of 125I within the genome results in marked cytotoxicity. Investigations of iodine-125 labeled iododeoxyuridine, DNA intercalators and tamoxifen are reviewed as representative of this new group of potential radiotherapeutic agents.
ISSN:	0360-3016 1879-355X
DOI:	10.1016/0360-3016(82)90448-5