Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State 19F NMR Spectroscopy

Design, Synthesis, and Application of a Trifluoromethylated Phenylalanine Analogue as a Label to Study Peptides by Solid-State 19F NMR Spectroscopy

Designer label: A novel α‐amino acid was designed as a conformationally restricted analogue of phenylalanine. It was synthesized and incorporated into the representative membrane‐active peptide Magainin 2, to demonstrate its suitablility for structure analysis in oriented membranes by solid‐state 19...

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Veröffentlicht in:Angewandte Chemie International Edition 2013-06, Vol.52 (25), p.6504-6507
Hauptverfasser: Tkachenko, Anton N., Radchenko, Dmytro S., Mykhailiuk, Pavel K., Afonin, Sergii, Ulrich, Anne S., Komarov, Igor V.
Format: Artikel
Sprache:eng
Schlagworte:
amino acids
Crystallography, X-Ray
Fluorine
Magnetic Resonance Spectroscopy - methods
Methylation
Models, Molecular
peptides
Peptides - chemistry
phenylalanine
Phenylalanine - chemistry
solid-state 19F NMR spectroscopy
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Beschreibung
Zusammenfassung:Designer label: A novel α‐amino acid was designed as a conformationally restricted analogue of phenylalanine. It was synthesized and incorporated into the representative membrane‐active peptide Magainin 2, to demonstrate its suitablility for structure analysis in oriented membranes by solid‐state 19F NMR spectroscopy.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201301344