Rh-Catalyzed Direct Enantioselective Alkynylation of α-Ketiminoesters

A green way to amino acids: α‐Tetrasubstituted α‐amino acid derivatives are formed in high yield and enantioselectivity by using a Rh‐catalyzed enantioselective alkynylation of α‐ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substr...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemistry : a European journal 2013-06, Vol.19 (26), p.8417-8420
Hauptverfasser:	Morisaki, Kazuhiro, Sawa, Masanao, Nomaguchi, Jun-ya, Morimoto, Hiroyuki, Takeuchi, Yosuke, Mashima, Kazushi, Ohshima, Takashi
Format:	Artikel
Sprache:	eng
Schlagworte:	alkynylation amino acids Amino Acids - chemistry asymmetric catalysis Catalysis Coordination Complexes - chemistry Esters Pargyline - analogs & derivatives Pargyline - chemistry Propylamines - chemistry Protons Rhodium - chemistry Stereoisomerism Temperature tetrasubstituted carbon atom α-ketiminoester
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A green way to amino acids: α‐Tetrasubstituted α‐amino acid derivatives are formed in high yield and enantioselectivity by using a Rh‐catalyzed enantioselective alkynylation of α‐ketiminoesters. This reaction, which involves a proton transfer and can be conducted at room temperature, has high substrate scope (see scheme; Cbz=benzyloxycarbonyl, Fmoc=9‐fluorenylmethyloxycarbonyl).
ISSN:	0947-6539 1521-3765
DOI:	10.1002/chem.201301237