Surgical treatment results of intestinal and diffuse type gastric cancer. Implications for a differentiated therapeutic approach?

Abstract Aim To study the outcome of patients who were surgically treated for primary gastric cancer with specific attention to differences in treatment results for intestinal and diffuse type tumours. Methods All patients who underwent a potentially curative gastric resection between 1995 and 2011...

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Veröffentlicht in:European journal of surgical oncology 2013-07, Vol.39 (7), p.686-693
Hauptverfasser: Stiekema, J, Cats, A, Kuijpers, A, van Coevorden, F, Boot, H, Jansen, E.P.M, Verheij, M, Balague Ponz, O, Hauptmann, M, van Sandick, J.W
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Sprache:eng
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Zusammenfassung:Abstract Aim To study the outcome of patients who were surgically treated for primary gastric cancer with specific attention to differences in treatment results for intestinal and diffuse type tumours. Methods All patients who underwent a potentially curative gastric resection between 1995 and 2011 in our institute were included. Patient, tumour and treatment characteristics were obtained retrospectively. Binary logistic and Cox regression models were used for multivariate analysis. Results A consecutive series of 132 patients was included. Median follow-up was 53 months. There were no significant differences between patients with intestinal ( N  = 62) versus diffuse type ( N  = 70) gastric cancer with regard to the proportion of patients who underwent (neo)adjuvant treatment. Postoperative mortality was 2%. Pathological T- and N-stage were significantly more advanced for patients with diffuse type tumours. There was a significant difference in the percentage of microscopically irradical resections (2% versus 24%, p  
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2013.02.026