Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1

Characterization of ciliary targeting sequence of rat melanin-concentrating hormone receptor 1

Highlights ► MCHR1 localizes to primary cilia when transiently expressed in hRPE1 cells. ► A242G in the third mutant intracellular loop reduces ciliary localization of MCHR1. ► The MCHR1 C-terminal tail seems unnecessary for its trafficking to the ciliary membrane. ► This study implies a relationshi...

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Veröffentlicht in:General and comparative endocrinology 2013-07, Vol.188, p.159-165
Hauptverfasser: Nagata, Asami, Hamamoto, Akie, Horikawa, Manabu, Yoshimura, Kentarou, Takeda, Sen, Saito, Yumiko
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Cell Line
central nervous system
cilia
Cilia - metabolism
endocrinology
Endocrinology & Metabolism
energy
G protein-coupled receptor
homeostasis
hRPE1 cells
Humans
linkage (genetics)
Melanin-concentrating hormone
membrane proteins
mice
Microscopy, Fluorescence
mutants
Mutation
obesity
polycystic kidney diseases
Primary cilia
Rats
Receptors, Somatostatin - metabolism
Targeting signal
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Zusammenfassung:Highlights ► MCHR1 localizes to primary cilia when transiently expressed in hRPE1 cells. ► A242G in the third mutant intracellular loop reduces ciliary localization of MCHR1. ► The MCHR1 C-terminal tail seems unnecessary for its trafficking to the ciliary membrane. ► This study implies a relationship between the ciliary MCH-MCHR1 system and ciliopathy.
ISSN:0016-6480
1095-6840
DOI:10.1016/j.ygcen.2013.02.020