How the ubiquitin proteasome system regulates the regulators of transcription

The ubiquitin proteasome system plays an important role in transcription. Monoubiquitination of activators is believed to aid their function, while the 26S proteasomal degradation of repressors is believed to restrict their function. What remains controversial is the question of whether the degradat...

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Veröffentlicht in:	Transcription 2012-09, Vol.3 (5), p.235-239
Hauptverfasser:	Ee, Gary, Lehming, Norbert
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience Calcium Cancer Cell conditional protein degradation Cycle Gal4 Landes Organogenesis Point of View Proteasome Endopeptidase Complex - metabolism Proteins transcription Transcription Factors - metabolism Transcription, Genetic ubiquitin Ubiquitin - metabolism Ubiquitination
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	The ubiquitin proteasome system plays an important role in transcription. Monoubiquitination of activators is believed to aid their function, while the 26S proteasomal degradation of repressors is believed to restrict their function. What remains controversial is the question of whether the degradation of activators aids or restricts their function.
ISSN:	2154-1264 2154-1272
DOI:	10.4161/trns.21249