Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice
Male and female mice, IOPS OF1 strain, received an i.p. injection of diazepam 1, 2, 4 or 8 mg/kg daily for 3 days prior to i.p. challenge with Klebsiella pneumoniae. Diazepam pretreatment increased mortality due to Klebsiella pneumoniae indicating that diazepam alters natural resistance to infection...
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| Veröffentlicht in: | Toxicology letters 1983-01, Vol.16 (3), p.281-284 |
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| container_title | Toxicology letters |
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| creator | Laschi, A. Descotes, J. Tachon, P. Evreux, J.C. |
| description | Male and female mice, IOPS OF1 strain, received an i.p. injection of diazepam 1, 2, 4 or 8 mg/kg daily for 3 days prior to i.p. challenge with
Klebsiella pneumoniae.
Diazepam pretreatment increased mortality due to
Klebsiella pneumoniae indicating that diazepam alters natural resistance to infection. The mechanism has not been elucidated but would appear to involve T cells and/or macrophages. |
| doi_str_mv | 10.1016/0378-4274(83)90188-1 |
| format | Article |
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Klebsiella pneumoniae.
Diazepam pretreatment increased mortality due to
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Klebsiella pneumoniae.
Diazepam pretreatment increased mortality due to
Klebsiella pneumoniae indicating that diazepam alters natural resistance to infection. The mechanism has not been elucidated but would appear to involve T cells and/or macrophages.</description><subject>Animals</subject><subject>Diazepam</subject><subject>Diazepam - toxicity</subject><subject>DL 50</subject><subject>Dose-Response Relationship, Drug</subject><subject>Female</subject><subject>Immunity, Innate - drug effects</subject><subject>immunotoxicity</subject><subject>Klebsiella Infections - immunology</subject><subject>Klebsiella pneumoniae</subject><subject>Klebsiella pneumoniae - pathogenicity</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Mice</subject><issn>0378-4274</issn><issn>1879-3169</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1983</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtLxDAUhYMo4zj6DxS6El1UkyZN0o0wDL5wwM0s3IU2uYFI29SkHdBfbzszuHR14Z5z7uND6JLgO4IJv8dUyJRlgt1IeltgImVKjtCcSFGklPDiGM3_LKfoLMZPjDFnPJ-hGaeMUSrm6GNpthAiJK619QCthsTbxLjyB7qySYbOt0mA6GJfTlrvk7caquigrsuka2FofOvKXRx070a3a5PGaThHJ7asI1wc6gJtnh43q5d0_f78ulquU02l7FMCBbbAbGYILylmOMdScCN4pquCa5FZXAksWUWZzoXRWZXrDBubZ9qSsbtA1_uxXfBfA8ReNS7q6boW_BAVoVxwQrLRyPZGHXyMAazqgmvK8K0IVhNPNcFSEywlqdrxHNMLdHWYP1QNmL_QAeCoP-x1GH_cOggqajdhNC6MQJTx7v8Fv-hrhQY</recordid><startdate>19830101</startdate><enddate>19830101</enddate><creator>Laschi, A.</creator><creator>Descotes, J.</creator><creator>Tachon, P.</creator><creator>Evreux, J.C.</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>7T5</scope><scope>7U7</scope><scope>C1K</scope><scope>H94</scope></search><sort><creationdate>19830101</creationdate><title>Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice</title><author>Laschi, A. ; Descotes, J. ; Tachon, P. ; Evreux, J.C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c388t-1e90fe4f2d16a304050876d762cb96c72f0b7084b34c57dc2b5c20df52cf14b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1983</creationdate><topic>Animals</topic><topic>Diazepam</topic><topic>Diazepam - toxicity</topic><topic>DL 50</topic><topic>Dose-Response Relationship, Drug</topic><topic>Female</topic><topic>Immunity, Innate - drug effects</topic><topic>immunotoxicity</topic><topic>Klebsiella Infections - immunology</topic><topic>Klebsiella pneumoniae</topic><topic>Klebsiella pneumoniae - pathogenicity</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>Mice</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Laschi, A.</creatorcontrib><creatorcontrib>Descotes, J.</creatorcontrib><creatorcontrib>Tachon, P.</creatorcontrib><creatorcontrib>Evreux, J.C.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Immunology Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Toxicology letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Laschi, A.</au><au>Descotes, J.</au><au>Tachon, P.</au><au>Evreux, J.C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice</atitle><jtitle>Toxicology letters</jtitle><addtitle>Toxicol Lett</addtitle><date>1983-01-01</date><risdate>1983</risdate><volume>16</volume><issue>3</issue><spage>281</spage><epage>284</epage><pages>281-284</pages><issn>0378-4274</issn><eissn>1879-3169</eissn><abstract>Male and female mice, IOPS OF1 strain, received an i.p. injection of diazepam 1, 2, 4 or 8 mg/kg daily for 3 days prior to i.p. challenge with
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Diazepam pretreatment increased mortality due to
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| fulltext | fulltext |
| identifier | ISSN: 0378-4274 |
| ispartof | Toxicology letters, 1983-01, Vol.16 (3), p.281-284 |
| issn | 0378-4274 1879-3169 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_13676112 |
| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Animals Diazepam Diazepam - toxicity DL 50 Dose-Response Relationship, Drug Female Immunity, Innate - drug effects immunotoxicity Klebsiella Infections - immunology Klebsiella pneumoniae Klebsiella pneumoniae - pathogenicity Lethal Dose 50 Male Mice |
| title | Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice |
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