Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice

Adverse influence of diazepam upon resistance to Klebsiella pneumoniae infection in mice

Male and female mice, IOPS OF1 strain, received an i.p. injection of diazepam 1, 2, 4 or 8 mg/kg daily for 3 days prior to i.p. challenge with Klebsiella pneumoniae. Diazepam pretreatment increased mortality due to Klebsiella pneumoniae indicating that diazepam alters natural resistance to infection...

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Veröffentlicht in:Toxicology letters 1983-01, Vol.16 (3), p.281-284
Hauptverfasser: Laschi, A., Descotes, J., Tachon, P., Evreux, J.C.
Format: Artikel
Sprache:eng
Schlagworte:
Animals
Diazepam
Diazepam - toxicity
DL 50
Dose-Response Relationship, Drug
Female
Immunity, Innate - drug effects
immunotoxicity
Klebsiella Infections - immunology
Klebsiella pneumoniae
Klebsiella pneumoniae - pathogenicity
Lethal Dose 50
Male
Mice
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Beschreibung
Zusammenfassung:Male and female mice, IOPS OF1 strain, received an i.p. injection of diazepam 1, 2, 4 or 8 mg/kg daily for 3 days prior to i.p. challenge with Klebsiella pneumoniae. Diazepam pretreatment increased mortality due to Klebsiella pneumoniae indicating that diazepam alters natural resistance to infection. The mechanism has not been elucidated but would appear to involve T cells and/or macrophages.
ISSN:0378-4274
1879-3169
DOI:10.1016/0378-4274(83)90188-1