Quantitative Genetics: Heritability Is Not Always Missing

Quantitative trait loci (QTLs) underlying multifactorial disorders explain little of the heritability — most is ‘missing’. A new yeast study has identified QTLs which explain most heritability in traits. Why is heritability missing in human diseases but not here?

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Bibliographische Detailangaben
Veröffentlicht in:	Current biology 2013-04, Vol.23 (7), p.R276-R278
1. Verfasser:	Brookfield, John F.Y.
Format:	Artikel
Sprache:	eng
Schlagworte:	Genetic Predisposition to Disease - genetics Genome-Wide Association Study - methods Genome-Wide Association Study - trends heritability human diseases Humans Inheritance Patterns - genetics Models, Genetic quantitative trait loci Quantitative Trait Loci - genetics Yeasts
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Quantitative trait loci (QTLs) underlying multifactorial disorders explain little of the heritability — most is ‘missing’. A new yeast study has identified QTLs which explain most heritability in traits. Why is heritability missing in human diseases but not here?
ISSN:	0960-9822 1879-0445
DOI:	10.1016/j.cub.2013.02.040