Thyrotropin-releasing hormone increases the number of muscarinic receptors in the lateral septal area of the rat brain

Stereotactic injection of acetylcholine (0.5–2 μg) into the lateral septal region of the rat brain produces a long-lasting sympathetic-mediated increase of the arterial blood pressure. This effect is mediated by muscarinic receptors since 1 μg atropine abolishes this response. In this same brain reg...

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Veröffentlicht in:	Brain research 1983-08, Vol.273 (2), p.387-391
Hauptverfasser:	Pirola, Carlos J., Balda, María S., Finkielman, Samuel, Nahmod, Víctor E.
Format:	Artikel
Sprache:	eng
Schlagworte:	acetylcholine Acetylcholine - administration & dosage Acetylcholine - pharmacology Animals blood pressure Blood Pressure - drug effects Drug Interactions lateral septal area Male muscarinic receptors pressor responses Rats Rats, Inbred Strains Receptors, Muscarinic - drug effects septum Septum Pellucidum - drug effects thyroliberin Thyrotropin-Releasing Hormone - administration & dosage Thyrotropin-Releasing Hormone - pharmacology TRH
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Beschreibung
Zusammenfassung:	Stereotactic injection of acetylcholine (0.5–2 μg) into the lateral septal region of the rat brain produces a long-lasting sympathetic-mediated increase of the arterial blood pressure. This effect is mediated by muscarinic receptors since 1 μg atropine abolishes this response. In this same brain region, TRH (0.5–4 μg) did not elicit any significant change in the arterial blood pressure, but potentiated the effect of acetylcholine. This phenomenon is apparently due to an increase of the number of muscarinic receptors in the lateral septal area of the rat brain.
ISSN:	0006-8993 1872-6240
DOI:	10.1016/0006-8993(83)90869-7