Predictors of Mortality and Outcomes of Therapy in Low-Flow Severe Aortic Stenosis: A Placement of Aortic Transcatheter Valves (PARTNER) Trial Analysis

The prognosis and treatment of patients with low-flow (LF) severe aortic stenosis are controversial. The Placement of Aortic Transcatheter Valves (PARTNER) trial randomized patients with severe aortic stenosis to medical management versus transcatheter aortic valve replacement (TAVR; inoperable coho...

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Veröffentlicht in:	Circulation (New York, N.Y.) N.Y.), 2013-06, Vol.127 (23), p.2316-2326
Hauptverfasser:	HERRMANN, Howard C, PIBAROT, Philippe, BAVARIA, Joseph E, KODALI, Susheel, HAHN, Rebecca T, WILLIAMS, Mathew, CRAIG MILLER, D, DOUGLAS, Pamela S, LEON, Martin B, HUETER, Irene, GERTZ, Zachary M, STEWART, William J, KAPADIA, Samir, MURAT TUZCU, E, BABALIAROS, Vasilis, THOURANI, Vinod, SZETO, Wilson Y
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Aortic Valve - pathology Aortic Valve - physiopathology Aortic Valve Stenosis - complications Aortic Valve Stenosis - diagnostic imaging Aortic Valve Stenosis - drug therapy Aortic Valve Stenosis - mortality Aortic Valve Stenosis - physiopathology Aortic Valve Stenosis - surgery Biological and medical sciences Bioprosthesis Blood and lymphatic vessels Blood Flow Velocity Cardiac Catheterization Cardiology. Vascular system Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous Endovascular Procedures Female Heart Valve Prosthesis Heart Valve Prosthesis Implantation - methods Humans Kaplan-Meier Estimate Male Medical sciences Organ Size Prognosis Proportional Hazards Models Prospective Studies Severity of Illness Index Stroke Volume Treatment Outcome Ultrasonography Ventricular Dysfunction, Left - complications Ventricular Dysfunction, Left - physiopathology Ventricular Remodeling
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Zusammenfassung:	The prognosis and treatment of patients with low-flow (LF) severe aortic stenosis are controversial. The Placement of Aortic Transcatheter Valves (PARTNER) trial randomized patients with severe aortic stenosis to medical management versus transcatheter aortic valve replacement (TAVR; inoperable cohort) and surgical aortic valve replacement versus TAVR (high-risk cohort). Among 971 patients with evaluable echocardiograms (92%), LF (stroke volume index ≤35 mL/m(2)) was observed in 530 (55%); LF and low ejection fraction (
ISSN:	0009-7322 1524-4539
DOI:	10.1161/CIRCULATIONAHA.112.001290