Atorvastatin suppresses glioma invasion and migration by reducing microglial MT1-MMP expression

Abstract Microglia, the immune cells of the brain, often present in large numbers in gliomas, where they promote tumor growth and invasiveness. This study found that atorvastatin reduced the pro-tumorigenic effects of microglia on glioma migration and invasion by reducing the microglial expression o...

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Veröffentlicht in:	Journal of neuroimmunology 2013-07, Vol.260 (1), p.1-8
Hauptverfasser:	Yongjun, Yi, Shuyun, Huang, Lei, Chen, Xiangrong, Chen, Zhilin, Yang, Yiquan, Ke
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergy and Immunology Atorvastatin Atorvastatin Calcium Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor Cell Movement - drug effects Gene Expression Regulation, Enzymologic - drug effects Gene Expression Regulation, Neoplastic - drug effects Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioma Heptanoic Acids - pharmacology Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology Invasion MAP Kinase Signaling System - drug effects Matrix Metalloproteinase 14 - genetics Matrix Metalloproteinase 14 - metabolism Matrix Metalloproteinase 2 - genetics Matrix Metalloproteinase 2 - metabolism Microglia Microglia - drug effects Microglia - metabolism Microglia - pathology Migration MT1-MMP Neoplasm Invasiveness - pathology Neurology p38 Mitogen-Activated Protein Kinases - metabolism Pyrroles - pharmacology
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Zusammenfassung:	Abstract Microglia, the immune cells of the brain, often present in large numbers in gliomas, where they promote tumor growth and invasiveness. This study found that atorvastatin reduced the pro-tumorigenic effects of microglia on glioma migration and invasion by reducing the microglial expression of membrane type 1 metalloproteinase (MT1-MMP). The results suggest that down-regulation of MT1-MMP is controlled by a p38 MAPK pathway in microglia. Taken together, the results support further research on atorvastatin as a candidate for glioma therapy by targeting microglia.
ISSN:	0165-5728 1872-8421
DOI:	10.1016/j.jneuroim.2013.04.020