The effect of medicaments used in endodontic regeneration on root fracture and microhardness of radicular dentine

Aim To investigate the effect of medicaments used in endodontic regeneration on root fracture resistance and microhardness of radicular dentine. Methodology The root canals of mandibular premolars (n = 180) were instrumented and randomized into three treatment groups and an untreated control group. Each treatment group received either triple antibiotic paste (TAP), double antibiotic paste (DAP) or calcium hydroxide paste [Ca(OH)2] intracanal medicament. Teeth were kept in saline for 1 week, 1 month or 3 months. After each time‐point, 15 teeth were randomly selected from each group and two root cylinders were obtained from each tooth. One cylinder was subjected to a fracture resistance test, and the other cylinder was used for a microhardness test. Two‐way anova and Tukey's pairwise comparisons were used for statistical analysis. Results For the microhardness test, the two‐way interaction between group and time was significant (P