Nrp2 deficiency leads to trabecular bone loss and is accompanied by enhanced osteoclast and reduced osteoblast numbers

Abstract Neuropilin 1 (Nrp1) and Nrp2 are transmembrane receptors that can bind class 3 semaphorins (Sema3A-G) in addition to VEGF family members to play important roles in axonal guidance, vascularization and angiogenesis, as well as immune responses. Moreover, recent evidence implicates Sema3A/Nrp...

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Veröffentlicht in:	Bone (New York, N.Y.) N.Y.), 2013-08, Vol.55 (2), p.465-475
Hauptverfasser:	Verlinden, Lieve, Kriebitzsch, Carsten, Beullens, Ine, Tan, Biauw Keng, Carmeliet, Geert, Verstuyf, Annemieke
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Biological and medical sciences Blotting, Western Bone and Bones - cytology Bone and Bones - metabolism Bone phenotype Cells, Cultured Diseases of the osteoarticular system Fundamental and applied biological sciences. Psychology Medical sciences Mice Mice, Inbred C57BL Mice, Knockout Neuropilin 2 Neuropilin-2 - genetics Neuropilin-2 - metabolism Orthopedics Osteoblast Osteoblasts - cytology Osteoblasts - metabolism Osteoclast Osteoclasts - cytology Osteoclasts - metabolism Osteogenesis - physiology Osteoporosis. Osteomalacia. Paget disease Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Semaphorin Vertebrates: anatomy and physiology, studies on body, several organs or systems
Online-Zugang:	Volltext
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