The ethics of creating children with three genetic parents

Abstract This article on mitochondrial replacement technology briefly explains and defends the legitimacy of such terms as ‘three-parent embryos’, ‘three-parent babies’ and ‘three-person IVF’. Next, it reviews select ethical objections to mitochondrial replacement technology that fall into four, sometimes overlapping, categories: (i) harms to egg providers; (ii) harms to potential offspring and future generations; (iii) harms to specific interest groups; and (iv) harms to society. Taken together, these ethical objections are cause for serious concern and yet the development and future use of mitochondrial replacement technology is likely inevitable.