Planar chiral [2.2]paracyclophane-based bis(thiourea) catalyst: application to asymmetric Henry reaction

Planar chiral [2.2]paracyclophane-based bis(thiourea) catalyst: application to asymmetric Henry reaction

A bis(thiourea) organocatalyst with a planar chiral [2.2]paracyclophane backbone has been synthesized and applied to the Henry reaction. The obtained high reactivity and enantioselectivity from the reaction of aromatic aldehydes with nitroalkanes suggested the significant potential of [2.2]paracyclo...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Chemical communications (Cambridge, England) England), 2013-01, Vol.49 (38), p.4030-4032
Hauptverfasser: Kitagaki, Shinji, Ueda, Takahiro, Mukai, Chisato
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Aldehydes - chemistry
Alkanes - chemistry
Asymmetry
Backbone
Catalysis
Catalysts
Ethers, Cyclic - chemistry
Hydrocarbons, Aromatic - chemistry
Models, Molecular
Nitro Compounds - chemistry
Piperidines - chemistry
Stereoisomerism
Thiourea - analogs & derivatives
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A bis(thiourea) organocatalyst with a planar chiral [2.2]paracyclophane backbone has been synthesized and applied to the Henry reaction. The obtained high reactivity and enantioselectivity from the reaction of aromatic aldehydes with nitroalkanes suggested the significant potential of [2.2]paracyclophane to serve as the backbone of the organocatalyst.
ISSN:1359-7345
1364-548X
DOI:10.1039/c3cc41789a