Computer simulation of macromolecular systems with amphiphilic monomer units: Biomimetic models

The review presents the basic models used to analyze the self-assembly of protein macromolecules and the main results of studying the self-organization of macromolecules in terms of the concepts of amphiphilicity of an individual monomer unit. The features of the coil-globule transition of these macro-molecules in solutions with different concentrations are described in terms of the statistics of the distribution of monomer units and chain rigidity. It is shown that this model is efficient for interpreting and analyzing experimental data for the study of synthetic and biological macromolecules.