Emerging roles of metaplasticity in behaviour and disease

Highlights • A framework for potential roles of metaplasticity in vivo is presented. • Metaplasticity can prepare synapses and networks for learning. • Metaplasticity can homeostatically keep synaptic plasticity within a dynamic range. • Metaplasticity mechanisms may play roles in disease and treatm...

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Veröffentlicht in:	Trends in neurosciences (Regular ed.) 2013-06, Vol.36 (6), p.353-362
Hauptverfasser:	Hulme, Sarah R, Jones, Owen D, Abraham, Wickliffe C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavior Behavior - physiology Behavior, Animal - physiology Cognition Disorders - physiopathology Cognition Disorders - therapy Conditioning, Classical - physiology Gene Expression Regulation - physiology Glutamic Acid - physiology Homeostasis Humans Learning Learning - physiology Memantine - pharmacology Memantine - therapeutic use Memory - physiology Mice Models, Neurological Models, Psychological Nerve Tissue Proteins - biosynthesis Nerve Tissue Proteins - genetics Nerve Tissue Proteins - physiology Neural networks Neurodegenerative Diseases - physiopathology Neurodegenerative Diseases - therapy Neurology Neuronal Plasticity - genetics Neuronal Plasticity - physiology Neurosciences Nootropic Agents - pharmacology Nootropic Agents - therapeutic use Rats Receptors, Ionotropic Glutamate - physiology Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors Receptors, N-Methyl-D-Aspartate - physiology Stroke - physiopathology Stroke - psychology Stroke - therapy Time Factors Transcranial Magnetic Stimulation Up-Regulation
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Zusammenfassung:	Highlights • A framework for potential roles of metaplasticity in vivo is presented. • Metaplasticity can prepare synapses and networks for learning. • Metaplasticity can homeostatically keep synaptic plasticity within a dynamic range. • Metaplasticity mechanisms may play roles in disease and treatment.
ISSN:	0166-2236 1878-108X
DOI:	10.1016/j.tins.2013.03.007