A new look at T cell receptor signaling to nuclear factor-κB

Highlights ► TCR activation of NF-κB involves a complex web of interconnected signal transducers. ► Many negative regulatory mechanisms cooperatively modulate the TCR-to-NF-κB pathway. ► Both a plasma membrane and a cytosolic signalosome participate in TCR signaling to NF-κB.

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Bibliographische Detailangaben
Veröffentlicht in:	Trends in immunology 2013-06, Vol.34 (6), p.269-281
Hauptverfasser:	Paul, Suman, Schaefer, Brian C
Format:	Artikel
Sprache:	eng
Schlagworte:	Active Transport, Cell Nucleus Allergy and Immunology Animals antigens Cell Nucleus - metabolism cell proliferation Humans Lymphocyte Activation Multiprotein Complexes - immunology Multiprotein Complexes - metabolism NF-kappa B - metabolism proteins Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction - immunology T-Lymphocytes - immunology transcription factor NF-kappa B
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Beschreibung
Zusammenfassung:	Highlights ► TCR activation of NF-κB involves a complex web of interconnected signal transducers. ► Many negative regulatory mechanisms cooperatively modulate the TCR-to-NF-κB pathway. ► Both a plasma membrane and a cytosolic signalosome participate in TCR signaling to NF-κB.
ISSN:	1471-4906 1471-4981
DOI:	10.1016/j.it.2013.02.002