A low-grade increase of serum pancreatic exocrine enzyme levels by dipeptidyl peptidase-4 inhibitor in patients with type 2 diabetes

Abstract A potential adverse effect of dipeptidyl peptidase-4 inhibitors (DPP-4i) on the pancreas remains controversial. We evaluated the DPP-4i effects on pancreatic amylase and lipase activity in patients with type 2 diabetes. These enzymes were slightly but significantly increased, suggesting DPP...

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Veröffentlicht in:	Diabetes research and clinical practice 2013-06, Vol.100 (3), p.e66-e69
Hauptverfasser:	Tokuyama, Hirotake, Kawamura, Harukiyo, Fujimoto, Masaki, Kobayashi, Kazuki, Nieda, Mie, Okazawa, Tetsuya, Takemoto, Minoru, Shimada, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Dipeptidyl-Peptidase IV Inhibitors - therapeutic use DPP-4 inhibitor Endocrinology & Metabolism Female Humans Lipase Lipase - blood Male Middle Aged Pancreas - drug effects Pancreas - enzymology Pancreatic alpha-Amylases - blood Pancreatic amylase Pancreatitis Pancreatitis - blood Retrospective Studies Type 2 diabetes mellitus
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Zusammenfassung:	Abstract A potential adverse effect of dipeptidyl peptidase-4 inhibitors (DPP-4i) on the pancreas remains controversial. We evaluated the DPP-4i effects on pancreatic amylase and lipase activity in patients with type 2 diabetes. These enzymes were slightly but significantly increased, suggesting DPP-4i cause a low-grade inflammatory change in the exocrine pancreas.
ISSN:	0168-8227 1872-8227
DOI:	10.1016/j.diabres.2013.03.034