Asymmetric Mannich Reaction of α-Keto Imines Catalyzed by Diarylprolinol Silyl Ether

Asymmetric Mannich Reaction of α-Keto Imines Catalyzed by Diarylprolinol Silyl Ether

Synthetic methods: An asymmetric catalytic, desulfonylative Mannich reaction of α‐keto imines with aldehydes, as catalyzed by diarylprolinol silyl ether 1, was developed. It gave the Mannich product in good yield with excellent anti and enantioselectivity (see scheme; Boc=tert‐butoxycarbonyl, TMS=tr...

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Veröffentlicht in:Chemistry : a European journal 2013-06, Vol.19 (24), p.7678-7681
Hauptverfasser: Hayashi, Yujiro, Sakamoto, Daisuke, Shomura, Hiroki, Hashizume, Daisuke
Format: Artikel
Sprache:eng
Schlagworte:
domino reactions
enantioselectivity
one-pot reaction
organocatalysis
synthetic methods
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Zusammenfassung:Synthetic methods: An asymmetric catalytic, desulfonylative Mannich reaction of α‐keto imines with aldehydes, as catalyzed by diarylprolinol silyl ether 1, was developed. It gave the Mannich product in good yield with excellent anti and enantioselectivity (see scheme; Boc=tert‐butoxycarbonyl, TMS=trimethylsilyl).
ISSN:0947-6539
1521-3765
DOI:10.1002/chem.201300513