Long-term Outcome and Quality of Life after Arterial Switch Operation: A Prospective Study with a Historical Comparison

Aim. The study aims to describe the long‐term cardiological and psychological results of our first surgical cohort of arterial switch operation (ASO) patients and compare the results with our earlier series of Mustard patients. Methods. Twenty‐four survivors of ASO operated in our center (1985–1990)...

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Veröffentlicht in:	Congenital heart disease 2013-05, Vol.8 (3), p.203-210
Hauptverfasser:	Ruys, Titia P.E., van der Bosch, Annemien E., Cuypers, Judith A.A.E., Witsenburg, Maarten, Helbing, Willem A., Bogers, Ad J.J.C., van Domburg, Ron, McGhie, Jacky S., Geleijnse, Marcel L., Henrichs, Jens, Utens, Elisabeth, Van der Zwaan, Heleen B., Takkenberg, Johanna J.M., Roos-Hesselink, Jolien W.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aortic Valve Insufficiency - etiology Aortic Valve Insufficiency - psychology Arterial Switch Cardiac Surgical Procedures - adverse effects Cardiac Surgical Procedures - mortality Cardiac Surgical Procedures - psychology Child, Preschool Disease-Free Survival Echocardiography Electrocardiography Electrocardiography, Ambulatory Exercise Test Exercise Tolerance Female Humans Infant, Newborn Kaplan-Meier Estimate Long-term Outcome Magnetic Resonance Imaging Male Mustard Operation Netherlands Predictive Value of Tests Prospective Studies Quality of Life Recovery of Function Surveys and Questionnaires Survival Time Factors Transposition of Great Vessels - mortality Transposition of Great Vessels - physiopathology Transposition of Great Vessels - psychology Transposition of Great Vessels - surgery Treatment Outcome Ventricular Function Young Adult
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Zusammenfassung:	Aim. The study aims to describe the long‐term cardiological and psychological results of our first surgical cohort of arterial switch operation (ASO) patients and compare the results with our earlier series of Mustard patients. Methods. Twenty‐four survivors of ASO operated in our center (1985–1990) were evaluated by electrocardiography, echocardiography, magnetic resonance imaging, exercise testing, 24‐hour Holter‐monitoring, and health‐related quality of life questionnaire. The results were compared with 58 adult Mustard patients who were evaluated in 2001 using the same study protocol. Results. Arterial switch operation was performed at a median age of 13 days and Mustard operation at 2 years. Median follow‐up was 22 years (range 20–25) and 25 years (22–29), respectively. After ASO, survival was better (P =.04). The event‐free survival after 22 years was 77% after ASO vs. 44% after Mustard (P =.03). Good systemic ventricular function was present in 93% after ASO vs. 6% after Mustard (P
ISSN:	1747-079X 1747-0803
DOI:	10.1111/chd.12033