A comparison of rapid point-of-care tests for the detection of avian influenza A(H7N9) virus, 2013

Six antigen detection-based rapid influenza point-of-care tests were compared for their ability to detect avian influenza A(H7N9) virus. The sensitivity of at least four tests, standardised by viral infectivity (TCID 50 ) or RNA copy number, was lower for the influenza A(H7N9) virus than for seasona...

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Veröffentlicht in:	Euro surveillance : bulletin européen sur les maladies transmissibles 2013-05, Vol.18 (21)
Hauptverfasser:	Baas, C, Barr, I G, Fouchier, R A, Kelso, A, Hurt, A C
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Viral - analysis Birds Humans Immunoassay - standards Influenza A virus - immunology Influenza A virus - isolation & purification Influenza in Birds - virology Influenza, Human - diagnosis Influenza, Human - virology Point-of-Care Systems Reagent Kits, Diagnostic Real-Time Polymerase Chain Reaction Sensitivity and Specificity
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Beschreibung
Zusammenfassung:	Six antigen detection-based rapid influenza point-of-care tests were compared for their ability to detect avian influenza A(H7N9) virus. The sensitivity of at least four tests, standardised by viral infectivity (TCID 50 ) or RNA copy number, was lower for the influenza A(H7N9) virus than for seasonal A(H3N2), A(H1N1)pdm09 or other recent avian A(H7) viruses. Comparing detection limits of A(H7N9) virus with Ct values of A(H7N9) clinical specimens suggests the tests would not have detected most clinical specimens.
ISSN:	1560-7917 1560-7917
DOI:	10.2807/ese.18.21.20487-en