Triterpenes with Cytotoxicity from the Leaves of Vernicia fordii

Two new triterpenes, (1α,3β,8α,9β,10α,13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2013/06/01, Vol.61(6), pp.674-677
Hauptverfasser:	Pei, Yi-Hua, Kwon, Ok-Kyoung, Lee, Ji-Seon, Cha, Hyuk-Jin, Ahn, Kyung-Seop, Oh, Sei-Ryang, Lee, Hyeong-Kyu, Chin, Young-Won
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Cell Survival - drug effects cytotoxicity Euphorbiaceae - chemistry Hep G2 Cells Humans Magnetic Resonance Spectroscopy Molecular Conformation Plant Leaves - chemistry triterpene Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - toxicity Vernicia fordii
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Beschreibung
Zusammenfassung:	Two new triterpenes, (1α,3β,8α,9β,10α,13α,14β)-9,10-dimethyl-25,26-dinorolean-5-en-1,3-diol (1) and (1α,3β,6β)-olean-12-en-1,3,6-triol (2) were isolated from the leaves of Aleurites fordii, together with five known triterpenes. The structures of isolates were established by one dimensional (1D)- and 2D-NMR spectroscopic data along with MS analysis. Of the isolated compounds, 1, 2 and 4 (daturadiol) displayed moderate cytotoxicities against two or more human cancer cell lines in HepG2 (hepatocellular carcinoma), SK-OV-3 (ovarian carcinoma), A-549 (lung carcinoma) and SNU-1 (gastric carcinoma).
ISSN:	0009-2363 1347-5223
DOI:	10.1248/cpb.c13-00055