The synthesis of l-α-aminoadipyl-l-cysteinyl-d-3,4-didehydrovaline, a potent inhibitor of isopenicillin synthetase

The synthesis of l-α-aminoadipyl-l-cysteinyl-d-3,4-didehydrovaline, a potent inhibitor of isopenicillin synthetase

The title peptide ( 1 ) has been synthesized and incubated with an active cell-free extract of Cephalosporium acremonium , no conversion to active antibiotics was observed; however on co-incubation with the Arnstein tripeptide (ACV) ( 2 ), strong inhibition of the conversion of ACV to isopenicillin...

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Veröffentlicht in:Tetrahedron 1982, Vol.38 (18), p.2773-2776
Hauptverfasser: Baldwin, Jack E., Chakravarti, Bulbul, Field, Leslie D., Murphy, John A., Whitten, Kathy R., Abraham, Sir Edward P., Jayatilake, Gamini
Format: Artikel
Sprache:eng
Schlagworte:
L- alpha -aminoadipyl-L-cysteinyl-D-3,4-didehydrovaline
peptide synthesis
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Zusammenfassung:The title peptide ( 1 ) has been synthesized and incubated with an active cell-free extract of Cephalosporium acremonium , no conversion to active antibiotics was observed; however on co-incubation with the Arnstein tripeptide (ACV) ( 2 ), strong inhibition of the conversion of ACV to isopenicillin N was observed.
ISSN:0040-4020
1464-5416
DOI:10.1016/0040-4020(82)85002-3