An aversive naloxone-morphine interaction in rats

An aversive naloxone-morphine interaction in rats

In a conditioned taste aversion (CTA) paradigm, male Wistar rats were injected intracerebroven-tricularly with a solution of either morphine (120 μg) or Ringer's vehicle following intraperitoneal injections of either naloxone (10 mg/kg) or Ringer's. Neither intracerebral morphine alone nor...

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Veröffentlicht in:Neuroscience letters 1983-03, Vol.35 (3), p.311-315
Hauptverfasser: Hunt, Tony, Amit, Zalman, Switzman, Lorne, Sinyor, David
Format: Artikel
Sprache:eng
Schlagworte:
Analysis of Variance
Animals
Aversive Therapy - methods
conditioned taste aversion
Drug Interactions
Injections, Intraventricular
intracranial administration
Male
morphine
Morphine - administration & dosage
Morphine - pharmacology
naloxone
Naloxone - pharmacology
rat
Rats
Rats, Inbred Strains
Taste
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Beschreibung
Zusammenfassung:In a conditioned taste aversion (CTA) paradigm, male Wistar rats were injected intracerebroven-tricularly with a solution of either morphine (120 μg) or Ringer's vehicle following intraperitoneal injections of either naloxone (10 mg/kg) or Ringer's. Neither intracerebral morphine alone nor intraperitoneal naloxone produced an aversion. The combination of central morphine plus peripheral naloxone did induce a significant and reliable CTA.
ISSN:0304-3940
1872-7972
DOI:10.1016/0304-3940(83)90336-1