Effect of tunicamycin treatment on the adherence of Candida albicans to human buccal epithelial cells

The work described here represents an alternative approach to the identification of the yeast ligand. It involved treating C. albicans with tunicamycin, an antibiotic which, in yeasts, specifically inhibits the synthesis of mannoprotein and not that of the other major wall components, glucan and chi...

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Veröffentlicht in:FEMS microbiology letters 1983-01, Vol.16 (2‐3), p.199-202
Hauptverfasser: Douglas, L.Julia, McCourtie, Jane
Format: Artikel
Sprache:eng
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Zusammenfassung:The work described here represents an alternative approach to the identification of the yeast ligand. It involved treating C. albicans with tunicamycin, an antibiotic which, in yeasts, specifically inhibits the synthesis of mannoprotein and not that of the other major wall components, glucan and chitin. The results suggest that yeast mannoprotein is of primary importance in the interaction with buccal epithelial cells.
ISSN:0378-1097
1574-6968
DOI:10.1111/j.1574-6968.1983.tb00287.x