Synthetic studies of the thieno[3,2-d]pyrimidine C-nucleoside isostere of inosine

Synthetic studies of the thieno[3,2-d]pyrimidine C-nucleoside isostere of inosine

Synthesis of the thieno(3,2-d)pyrimidine C-nucleoside isostere of inosine was achieved via a two-step ring closure of C-4 ribosylated methyl 3-aminothiophene-2-carboxylate by reaction of 3-aminothiophene-2-carboxamide with triethyl orthoformate.

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Veröffentlicht in:Journal of organic chemistry 1982-11, Vol.47 (24), p.4633-4637
Hauptverfasser: Ren, Wu Yun, Lim, Mu Ill, Otter, Brian A, Klein, Robert S
Format: Artikel
Sprache:eng
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Zusammenfassung:Synthesis of the thieno(3,2-d)pyrimidine C-nucleoside isostere of inosine was achieved via a two-step ring closure of C-4 ribosylated methyl 3-aminothiophene-2-carboxylate by reaction of 3-aminothiophene-2-carboxamide with triethyl orthoformate.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo00145a005