Preliminary report on a comparative trial of cefotetan and cefoxitin in the treatment of urinary tract infections

Cefotetan was compared with cefoxitin in the treatment of hospitalized patients with complicated as well as uncomplicated urinary tract infections. Cefotetan produced high peak and trough plasma and urine concentrations with a twice-daily dosing schedule. The intravenous administration of 1 or 2 g of cefotetan every 12 h was effective in treating urinary tract infections due to susceptible Gram-negative bacteria and compared favourably with the results obtained with 1 or 2 g of cefoxitin every 8 h. Similar types of non-serious adverse reactions occurred with both drugs.