Orthotopic implantation of primary N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide-induced bladder cancer in bladder submucosa: An animal model for bladder cancer study

Primary bladder tumors induced in Fischer 344 inbred rats by N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide were transplanted in syngeneic rats by the intravesical, s.c., i.v., and orthotopic routes. Attempts were made to establish bladder cancer cell lines in vitro. The techniques of orthotopic impla...

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Veröffentlicht in:Cancer research (Chicago, Ill.) Ill.), 1983-01, Vol.43 (2), p.617-622
Hauptverfasser: Ibrahiem, E I, Nigam, V N, Brailovsky, CA, Madarnas, P, Elhilali, M
Format: Artikel
Sprache:eng
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Zusammenfassung:Primary bladder tumors induced in Fischer 344 inbred rats by N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide were transplanted in syngeneic rats by the intravesical, s.c., i.v., and orthotopic routes. Attempts were made to establish bladder cancer cell lines in vitro. The techniques of orthotopic implantation as well as the usefulness of this tumor model for bladder cancer studies are described.
ISSN:0008-5472