Death of multiple myeloma cells induced by cAMP-signaling involves downregulation of Mcl-1 via the JAK/STAT pathway

Highlights ► We investigated the mechanisms whereby cAMP induces apoptosis in human multiple myeloma cells. ► Expression of the pro-survival protein MCL-1was rapidly and selectively reduced by cAMP. ► cAMP inhibited the JAK/STAT pathway which is known to regulate MCL-1 transcription. ► Exogenous IL-...

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Veröffentlicht in:	Cancer letters 2013-07, Vol.335 (2), p.323-331
Hauptverfasser:	Follin-Arbelet, Virginie, Torgersen, Maria Lyngaas, Naderi, Elin Hallan, Misund, Kristine, Sundan, Anders, Blomhoff, Heidi Kiil
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Bone marrow cAMP Cancer Cell Line, Tumor Colforsin - pharmacology Cyclic AMP - metabolism Down-Regulation Flow cytometry Hematology, Oncology and Palliative Medicine Humans Interleukin-6 - pharmacology JAK Janus Kinase 1 - antagonists & inhibitors Janus Kinase 1 - metabolism Kinases Mcl-1 Multiple myeloma Multiple Myeloma - drug therapy Multiple Myeloma - metabolism Myeloid Cell Leukemia Sequence 1 Protein Phosphorylation Proteins Proto-Oncogene Proteins c-bcl-2 - biosynthesis Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism Rodents Signal Transduction STAT STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - metabolism Syndecan-1 - metabolism
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Zusammenfassung:	Highlights ► We investigated the mechanisms whereby cAMP induces apoptosis in human multiple myeloma cells. ► Expression of the pro-survival protein MCL-1was rapidly and selectively reduced by cAMP. ► cAMP inhibited the JAK/STAT pathway which is known to regulate MCL-1 transcription. ► Exogenous IL-6 did not prevent cAMP-mediated inhibition of the JAK/STAT pathway or the cell death. ► Modulation of cAMP-signaling is a promising target for treatment of multiple myeloma.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.02.042