Hyaluronic acid-coated nanostructured lipid carriers for targeting paclitaxel to cancer

Highlights ► We successfully prepared hyaluronic acid coated, paclitaxel loaded, nanostructured lipid carriers (HA-NLCs) via electrostatic attraction. ► The in vitro cytotoxicity of HA-NLCs was superior to that of Taxol® in B16, CT26 and HCT116 cell lines. ► The in vivo antitumor effect of HA-NLCs i...

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Veröffentlicht in:	Cancer letters 2013-07, Vol.334 (2), p.338-345
Hauptverfasser:	Yang, Xiao-yan, Li, Yun-xia, Li, Min, Zhang, Li, Feng, Li-xia, Zhang, Na
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacokinetics Aqueous solutions Biocompatibility Cancer CD44 Chemical bonds Chemical reactions Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Crystal structure Cytotoxicity Drug Carriers - administration & dosage Drug Carriers - chemistry Drug Delivery Systems - methods Female HCT116 Cells Hematology, Oncology and Palliative Medicine Humans Hyaluronic acid Hyaluronic Acid - administration & dosage Hyaluronic Acid - chemistry Hyaluronic Acid - pharmacokinetics Lipids Lipids - administration & dosage Lipids - chemistry Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism Mice Molecular weight Nanoparticles Nanostructured lipid carriers Nanostructures - administration & dosage Nanostructures - chemistry Paclitaxel Paclitaxel - administration & dosage Paclitaxel - chemistry Paclitaxel - pharmacokinetics Pharmaceuticals Random Allocation Skin care products Studies Tumor target Tumors Vegetable oils
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Beschreibung
Zusammenfassung:	Highlights ► We successfully prepared hyaluronic acid coated, paclitaxel loaded, nanostructured lipid carriers (HA-NLCs) via electrostatic attraction. ► The in vitro cytotoxicity of HA-NLCs was superior to that of Taxol® in B16, CT26 and HCT116 cell lines. ► The in vivo antitumor effect of HA-NLCs in B16-bearing Kunming mice was extremely promising. ► HA-NLC prepared via electrostatic attraction was an effective carrier for delivering paclitaxel PTX to tumors overexpressing CD44.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2012.07.002