Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA

Highlights ► Mdm2 binds to the Slug mRNA and increases its stability regardless of p53 expression. ► Mdm2 increases the Slug protein levels and cellular invasiveness selectively in p53-null cells. ► The stabilization of Slug mRNA is a novel mechanism whereby Mdm2 promotes tumor progression in a p53-...

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Veröffentlicht in:	Cancer letters 2013-07, Vol.335 (2), p.270-277
Hauptverfasser:	Jung, Chan-Hun, Kim, Jongdoo, Park, Jong Kuk, Hwang, Sang-Gu, Moon, Sung-Kwon, Kim, Wun-Jae, Um, Hong-Duck
Format:	Artikel
Sprache:	eng
Schlagworte:	Cadherins - metabolism Cancer Cancer therapies Cell Line, Tumor Cloning Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Genes Hematology, Oncology and Palliative Medicine Humans Invasion Lung Neoplasms - metabolism Lung Neoplasms - pathology Mdm2 Mutagenesis Neoplasm Invasiveness p53 Proteins Proto-Oncogene Proteins c-mdm2 - metabolism R&D Research & development RNA, Messenger - metabolism Slug Snail Family Transcription Factors Transcription Factors - genetics Tumor Suppressor Protein p53 Tumors
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Zusammenfassung:	Highlights ► Mdm2 binds to the Slug mRNA and increases its stability regardless of p53 expression. ► Mdm2 increases the Slug protein levels and cellular invasiveness selectively in p53-null cells. ► The stabilization of Slug mRNA is a novel mechanism whereby Mdm2 promotes tumor progression in a p53-independent manner.
ISSN:	0304-3835 1872-7980
DOI:	10.1016/j.canlet.2013.02.035