Asthma medication delivery: Mists and myths

Summary Asthma is usually treated with inhaled corticosteroids (ICS) and bronchodilators generated from pressurized metered dose inhalers (pMDI), dry powder inhalers (DPI), or nebulizers. The target areas for ICS and beta 2-agonists in the treatment of asthma are explained. Drug deposition not only...

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Veröffentlicht in:	Paediatric respiratory reviews 2013-06, Vol.14 (2), p.112-118
Hauptverfasser:	Rottier, Bart L, Rubin, Bruce K
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Inhalation Adrenal Cortex Hormones - administration & dosage Aerosol Asthma - drug therapy Bronchodilator Agents - administration & dosage Child Dry powder inhaler Dry Powder Inhalers Humans Lung deposition Metered Dose Inhalers Nebulizer Pediatrics Pressurized metered dose inhaler Pulmonary/Respiratory Treatment Outcome
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Zusammenfassung:	Summary Asthma is usually treated with inhaled corticosteroids (ICS) and bronchodilators generated from pressurized metered dose inhalers (pMDI), dry powder inhalers (DPI), or nebulizers. The target areas for ICS and beta 2-agonists in the treatment of asthma are explained. Drug deposition not only depends on particle size, but also on inhalation manoeuvre. Myths regarding inhalation treatments lead to less than optimal use of these delivery systems. We discuss the origin of many of these myths and provide the background and evidence for rejecting them.
ISSN:	1526-0542 1526-0550
DOI:	10.1016/j.prrv.2013.02.013