Toxic Multinodular Goiter with Low Radioactive Iodine Uptake

A 74-year-old woman was referred to our hospital for goiter and persistent thyrotoxicosis. She had no signs of ophthalmopathy. She was not taking thyroid hormone. Thyroid CT revealed multiple nodules. The thyroid gland was not detected on 99mTc scintigraphy, 123I uptake rate was 4.5% at 24 hours wit...

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Veröffentlicht in:	Internal Medicine 2011, Vol.50(16), pp.1709-1714
Hauptverfasser:	Kahara, Toshio, Shimizu, Akiko, Uchiyama, Akio, Terahata, Shintaro, Tajiri, Junichi, Nishihara, Eijun, Miyauchi, Akira, Abo, Hitoshi, Sumiya, Hisashi, Ishikura, Kazuhide, Usuda, Rika, Noto, Hirofumi
Format:	Artikel
Sprache:	eng
Schlagworte:	99mtechnetium Aged Female Goiter, Nodular - diagnosis Goiter, Nodular - metabolism Goiter, Nodular - surgery Humans hyperthyroidism Iodine Radioisotopes - metabolism radioactive iodine uptake SPECT thyrotoxicosis Thyrotoxicosis - diagnosis Thyrotoxicosis - metabolism Thyrotoxicosis - surgery toxic multinodular goiter
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Zusammenfassung:	A 74-year-old woman was referred to our hospital for goiter and persistent thyrotoxicosis. She had no signs of ophthalmopathy. She was not taking thyroid hormone. Thyroid CT revealed multiple nodules. The thyroid gland was not detected on 99mTc scintigraphy, 123I uptake rate was 4.5% at 24 hours without hot nodules, and aberrant goiter was negative. After partial thyroidectomy, she was treated with levothyroxine. TRAb was undetectable during the disease course, and focal destructive change or chronic lymphocytic thyroiditis on the pathological specimens was not evident. We report a rare case of toxic multinodular goiter with low radioactive iodine uptake.
ISSN:	0918-2918 1349-7235 1349-7235
DOI:	10.2169/internalmedicine.50.5256