Use of Clinical Practice Guidelines on Long-term Prophylaxis in Severe Hemophilia in France: A Retrospective Audit

Objectives To evaluate the impact of the 2002 guidelines on the current status of prophylaxis in French children with severe hemophilia A or B. Study design Clinical information was captured, in a prospective way, using FranceCoag Network. We retrospectively studied 291 patients with severe (3 years of age are now receiving prophylaxis. In severe hemophilia A and B, the age at which prophylaxis commences has significantly decreased: 4.0 and 6.1 years for the period 1996-1999 as opposed to 1.8 and 1.4 years for the period 2004-2007 ( P = .0001). Conclusions Long-term clinical and physical evaluations of patients will be necessary to establish the benefits of this increase in prophylactic treatment on the prevention of hemophilic arthropathy.