Rhazinilam–Leuconolam–Leuconoxine Alkaloids from Leuconotis griffithii

Eight new indole alkaloids (1–8) belonging to the rhazinilam–leuconolam–leuconoxine group, in addition to 52 other alkaloids, were isolated from the stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and leuconodines...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2013-05, Vol.76 (5), p.957-964
Hauptverfasser:	Gan, Chew-Yan, Low, Yun-Yee, Thomas, Noel F, Kam, Toh-Seok
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Apocynaceae - chemistry Azepines - chemistry Crystallography, X-Ray Drug Resistance, Neoplasm - drug effects Drug Screening Assays, Antitumor Heterocyclic Compounds, 4 or More Rings - chemistry Humans Indolizines - chemistry KB Cells Lactams - chemistry Malaysia Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Plant Bark - chemistry Vincristine - pharmacology
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