Rhazinilam–Leuconolam–Leuconoxine Alkaloids from Leuconotis griffithii

Eight new indole alkaloids (1–8) belonging to the rhazinilam–leuconolam–leuconoxine group, in addition to 52 other alkaloids, were isolated from the stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and leuconodines...

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Veröffentlicht in:Journal of natural products (Washington, D.C.) D.C.), 2013-05, Vol.76 (5), p.957-964
Hauptverfasser: Gan, Chew-Yan, Low, Yun-Yee, Thomas, Noel F, Kam, Toh-Seok
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Sprache:eng
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Zusammenfassung:Eight new indole alkaloids (1–8) belonging to the rhazinilam–leuconolam–leuconoxine group, in addition to 52 other alkaloids, were isolated from the stem-bark extract of Leuconotis griffithii, viz., nor-rhazinicine (1), 5,21-dihydrorhazinilam-N-oxide (2), 3,14-dehydroleuconolam (3), and leuconodines A–E (4–8). The structures of these alkaloids were determined using NMR and MS analyses and in some instances confirmed by X-ray diffraction analyses. Alkaloids 1, 5, and 7 showed only moderate to weak cytotoxicity toward KB cells (IC50 12–18 μg/mL), while 8 showed moderate activity in reversing MDR in vincristine-resistant KB cells.
ISSN:0163-3864
1520-6025
DOI:10.1021/np400214y