Norfriedelins A–C with Acetylcholinesterase Inhibitory Activity from Acerola Tree (Malpighia emarginata)

Three novel norfriedelanes, A–C (1–3), were isolated from the branches and roots of Malpighia emarginata. Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an α-oxo-β-lactone group) and norfriedeli...

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Veröffentlicht in:	Organic letters 2013-04, Vol.15 (7), p.1580-1583
Hauptverfasser:	Liu, Jie-Qing, Peng, Xing-Rong, Li, Xu-Yang, Li, Ting-Zhao, Zhang, Wei-Ming, Shi, Lei, Han, Jiang, Qiu, Ming-Hua
Format:	Artikel
Sprache:	eng
Schlagworte:	Cholinesterase Inhibitors - chemistry Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Crystallography, X-Ray Inhibitory Concentration 50 Malpighiaceae - chemistry Molecular Conformation Molecular Structure Nuclear Magnetic Resonance, Biomolecular Triterpenes - chemistry Triterpenes - isolation & purification Triterpenes - pharmacology
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Zusammenfassung:	Three novel norfriedelanes, A–C (1–3), were isolated from the branches and roots of Malpighia emarginata. Their structures and absolute configurations were determined by 1D and 2D NMR techniques and X-ray crystallographic analysis. Norfriedelin A (possessing an α-oxo-β-lactone group) and norfriedelin B (with a keto-lactone group) showed acetylcholinesterase inhibitory effects with the IC50 values of 10.3 and 28.7 μM, respectively.
ISSN:	1523-7060 1523-7052
DOI:	10.1021/ol4003702