Independent induction of intestinal metaplasia and gastric cancer in rats treated with N-methyl-N'-nitro-N-nitrosoguanidine

Intestinal metaplasia in pyloric mucosa and presence of intestinal-type tumor cells in gastric tumors in Wistar rats during gastrocarcinogenesis were examined by paradoxical concanavalin A staining and biochemical pepsinogen (Pg) assay. Gastric cancer was induced by N-methyl-N'-nitro-N-nitrosog...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1983-03, Vol.43 (3), p.1335-1341
Hauptverfasser:	Tatematsu, M, Furihata, C, Katsuyama, T, Hasegawa, R, Nakanowatari, J, Saito, D, Takahashi, M, Matsushima, T, Ito, N
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma - chemically induced Animals Intestines - pathology Isoenzymes - analysis Male Metaplasia - chemically induced Methylnitronitrosoguanidine Models, Biological Pepsinogens - analysis Pylorus - enzymology Pylorus - pathology Rats Rats, Inbred Strains Stomach Neoplasms - chemically induced
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Zusammenfassung:	Intestinal metaplasia in pyloric mucosa and presence of intestinal-type tumor cells in gastric tumors in Wistar rats during gastrocarcinogenesis were examined by paradoxical concanavalin A staining and biochemical pepsinogen (Pg) assay. Gastric cancer was induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) given in drinking water at a level of 50 mu g/ml for either 16 weeks (Group 1) or 8 weeks (Group 2). Changes associated with MNNG treatment included intestinal metaplasia of pyloric mucosa, adenomatous hyperplasia of pyloric mucosa, and well-differentiated adenocarcinoma of pyloric mucosa.
ISSN:	0008-5472