Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer
The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical st...
Gespeichert in:
| Veröffentlicht in: | Endocrine-related cancer 2013-06, Vol.20 (3), p.339-348 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 348 |
|---|---|
| container_issue | 3 |
| container_start_page | 339 |
| container_title | Endocrine-related cancer |
| container_volume | 20 |
| creator | Kim, Sewha Kim, Do Hee Jung, Woo-Hee Koo, Ja Seung |
| description | The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. Breast cancers were classified as follows: 293 luminal A (41.7%), 166 luminal B (23.6%), 67 HER2 type (9.6%), and 176 TNBC (25.1%). HER2 type showed the highest stromal GLS1 (P=0.001), tumoral GDH (P=0.001), stromal GDH (P |
| doi_str_mv | 10.1530/ERC-12-0398 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1354791295</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1354791295</sourcerecordid><originalsourceid>FETCH-LOGICAL-b476t-b1f8f5a8032d61cde6dbff0f9fac5eb7f815bf159d87144c9e035fcc5274b2bf3</originalsourceid><addsrcrecordid>eNp9kM1LwzAYh4MoTqcn75KjINGkbdr0KGN-wEAQPYckfTMibTOTFNx_b8amR0_ve3h4-PEgdMXoHeMlvV--LQgrCC1bcYTOWNW0pBYFO85_yRmhVIgZOo_xk1JaC85P0awoOW0aWp0hs_zeBIjR-RF7i9f9lNTgRsADJKV97-JAAvQqQYc3wSdwY8TKGB86N65x8njwPZipVwHHSaftBnYeHUDFhI0aDYQLdGJVH-HycOfo43H5vngmq9enl8XDiuiqqRPRzArLlaBl0dXMdFB32lpqW6sMB91Ywbi2jLedaFhVmRZoya0xvGgqXWhbztHN3puHfk0QkxxcNND3agQ_RZlz5DisaHlGb_eoCT7GAFZughtU2EpG5a6qzFUlK-SuaqavD-JJD9D9sb8ZM8D2gHY-GgdjctYZ9a_0B_VbhRk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1354791295</pqid></control><display><type>article</type><title>Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer</title><source>MEDLINE</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><source>Society for Endocrinology Journals</source><creator>Kim, Sewha ; Kim, Do Hee ; Jung, Woo-Hee ; Koo, Ja Seung</creator><creatorcontrib>Kim, Sewha ; Kim, Do Hee ; Jung, Woo-Hee ; Koo, Ja Seung</creatorcontrib><description>The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. Breast cancers were classified as follows: 293 luminal A (41.7%), 166 luminal B (23.6%), 67 HER2 type (9.6%), and 176 TNBC (25.1%). HER2 type showed the highest stromal GLS1 (P=0.001), tumoral GDH (P=0.001), stromal GDH (P<0.001), and tumoral ASCT (P<0.001) expression. We identified differential expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer. The highest glutamine metabolic activity was seen in HER2-type breast cancer.</description><identifier>ISSN: 1351-0088</identifier><identifier>EISSN: 1479-6821</identifier><identifier>DOI: 10.1530/ERC-12-0398</identifier><identifier>PMID: 23507704</identifier><language>eng</language><publisher>England: Society for Endocrinology</publisher><subject>Adult ; Amino Acid Transport System ASC - metabolism ; Breast Neoplasms - classification ; Breast Neoplasms - metabolism ; Carcinoma, Ductal, Breast - classification ; Carcinoma, Ductal, Breast - metabolism ; Female ; Glutamate Dehydrogenase - metabolism ; Glutaminase - metabolism ; Glutamine - metabolism ; Humans ; Middle Aged ; Minor Histocompatibility Antigens ; Phenotype ; Tissue Array Analysis</subject><ispartof>Endocrine-related cancer, 2013-06, Vol.20 (3), p.339-348</ispartof><rights>2013 Society for Endocrinology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b476t-b1f8f5a8032d61cde6dbff0f9fac5eb7f815bf159d87144c9e035fcc5274b2bf3</citedby><cites>FETCH-LOGICAL-b476t-b1f8f5a8032d61cde6dbff0f9fac5eb7f815bf159d87144c9e035fcc5274b2bf3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,3936,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23507704$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kim, Sewha</creatorcontrib><creatorcontrib>Kim, Do Hee</creatorcontrib><creatorcontrib>Jung, Woo-Hee</creatorcontrib><creatorcontrib>Koo, Ja Seung</creatorcontrib><title>Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer</title><title>Endocrine-related cancer</title><addtitle>Endocr Relat Cancer</addtitle><description>The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. Breast cancers were classified as follows: 293 luminal A (41.7%), 166 luminal B (23.6%), 67 HER2 type (9.6%), and 176 TNBC (25.1%). HER2 type showed the highest stromal GLS1 (P=0.001), tumoral GDH (P=0.001), stromal GDH (P<0.001), and tumoral ASCT (P<0.001) expression. We identified differential expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer. The highest glutamine metabolic activity was seen in HER2-type breast cancer.</description><subject>Adult</subject><subject>Amino Acid Transport System ASC - metabolism</subject><subject>Breast Neoplasms - classification</subject><subject>Breast Neoplasms - metabolism</subject><subject>Carcinoma, Ductal, Breast - classification</subject><subject>Carcinoma, Ductal, Breast - metabolism</subject><subject>Female</subject><subject>Glutamate Dehydrogenase - metabolism</subject><subject>Glutaminase - metabolism</subject><subject>Glutamine - metabolism</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Minor Histocompatibility Antigens</subject><subject>Phenotype</subject><subject>Tissue Array Analysis</subject><issn>1351-0088</issn><issn>1479-6821</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM1LwzAYh4MoTqcn75KjINGkbdr0KGN-wEAQPYckfTMibTOTFNx_b8amR0_ve3h4-PEgdMXoHeMlvV--LQgrCC1bcYTOWNW0pBYFO85_yRmhVIgZOo_xk1JaC85P0awoOW0aWp0hs_zeBIjR-RF7i9f9lNTgRsADJKV97-JAAvQqQYc3wSdwY8TKGB86N65x8njwPZipVwHHSaftBnYeHUDFhI0aDYQLdGJVH-HycOfo43H5vngmq9enl8XDiuiqqRPRzArLlaBl0dXMdFB32lpqW6sMB91Ywbi2jLedaFhVmRZoya0xvGgqXWhbztHN3puHfk0QkxxcNND3agQ_RZlz5DisaHlGb_eoCT7GAFZughtU2EpG5a6qzFUlK-SuaqavD-JJD9D9sb8ZM8D2gHY-GgdjctYZ9a_0B_VbhRk</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Kim, Sewha</creator><creator>Kim, Do Hee</creator><creator>Jung, Woo-Hee</creator><creator>Koo, Ja Seung</creator><general>Society for Endocrinology</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130601</creationdate><title>Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer</title><author>Kim, Sewha ; Kim, Do Hee ; Jung, Woo-Hee ; Koo, Ja Seung</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b476t-b1f8f5a8032d61cde6dbff0f9fac5eb7f815bf159d87144c9e035fcc5274b2bf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Amino Acid Transport System ASC - metabolism</topic><topic>Breast Neoplasms - classification</topic><topic>Breast Neoplasms - metabolism</topic><topic>Carcinoma, Ductal, Breast - classification</topic><topic>Carcinoma, Ductal, Breast - metabolism</topic><topic>Female</topic><topic>Glutamate Dehydrogenase - metabolism</topic><topic>Glutaminase - metabolism</topic><topic>Glutamine - metabolism</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Minor Histocompatibility Antigens</topic><topic>Phenotype</topic><topic>Tissue Array Analysis</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kim, Sewha</creatorcontrib><creatorcontrib>Kim, Do Hee</creatorcontrib><creatorcontrib>Jung, Woo-Hee</creatorcontrib><creatorcontrib>Koo, Ja Seung</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Endocrine-related cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kim, Sewha</au><au>Kim, Do Hee</au><au>Jung, Woo-Hee</au><au>Koo, Ja Seung</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer</atitle><jtitle>Endocrine-related cancer</jtitle><addtitle>Endocr Relat Cancer</addtitle><date>2013-06-01</date><risdate>2013</risdate><volume>20</volume><issue>3</issue><spage>339</spage><epage>348</epage><pages>339-348</pages><issn>1351-0088</issn><eissn>1479-6821</eissn><abstract>The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. Breast cancers were classified as follows: 293 luminal A (41.7%), 166 luminal B (23.6%), 67 HER2 type (9.6%), and 176 TNBC (25.1%). HER2 type showed the highest stromal GLS1 (P=0.001), tumoral GDH (P=0.001), stromal GDH (P<0.001), and tumoral ASCT (P<0.001) expression. We identified differential expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer. The highest glutamine metabolic activity was seen in HER2-type breast cancer.</abstract><cop>England</cop><pub>Society for Endocrinology</pub><pmid>23507704</pmid><doi>10.1530/ERC-12-0398</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1351-0088 |
| ispartof | Endocrine-related cancer, 2013-06, Vol.20 (3), p.339-348 |
| issn | 1351-0088 1479-6821 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1354791295 |
| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection; Society for Endocrinology Journals |
| subjects | Adult Amino Acid Transport System ASC - metabolism Breast Neoplasms - classification Breast Neoplasms - metabolism Carcinoma, Ductal, Breast - classification Carcinoma, Ductal, Breast - metabolism Female Glutamate Dehydrogenase - metabolism Glutaminase - metabolism Glutamine - metabolism Humans Middle Aged Minor Histocompatibility Antigens Phenotype Tissue Array Analysis |
| title | Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-28T23%3A51%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Expression%20of%20glutamine%20metabolism-related%20proteins%20according%20to%20molecular%20subtype%20of%20breast%20cancer&rft.jtitle=Endocrine-related%20cancer&rft.au=Kim,%20Sewha&rft.date=2013-06-01&rft.volume=20&rft.issue=3&rft.spage=339&rft.epage=348&rft.pages=339-348&rft.issn=1351-0088&rft.eissn=1479-6821&rft_id=info:doi/10.1530/ERC-12-0398&rft_dat=%3Cproquest_cross%3E1354791295%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1354791295&rft_id=info:pmid/23507704&rfr_iscdi=true |