Expression of glutamine metabolism-related proteins according to molecular subtype of breast cancer

The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical st...

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Veröffentlicht in:	Endocrine-related cancer 2013-06, Vol.20 (3), p.339-348
Hauptverfasser:	Kim, Sewha, Kim, Do Hee, Jung, Woo-Hee, Koo, Ja Seung
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Amino Acid Transport System ASC - metabolism Breast Neoplasms - classification Breast Neoplasms - metabolism Carcinoma, Ductal, Breast - classification Carcinoma, Ductal, Breast - metabolism Female Glutamate Dehydrogenase - metabolism Glutaminase - metabolism Glutamine - metabolism Humans Middle Aged Minor Histocompatibility Antigens Phenotype Tissue Array Analysis
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Zusammenfassung:	The aim of this study was to investigate the expression of glutamine metabolism-related proteins to determine whether glutamine is metabolized differently according to breast cancer molecular subtype. We generated a tissue microarray of 702 breast cancer patients and performed immunohistochemical staining for glutamine metabolism-related proteins, including glutaminase 1 (GLS1 (GLS)), glutamate dehydrogenase (GDH (H6PD)), and amino acid transporter-2 (ASCT2 (SLC1A5)), which were separately evaluated in tumor and stroma compartments and then analyzed by breast cancer molecular subtypes. Breast cancers were classified as follows: 293 luminal A (41.7%), 166 luminal B (23.6%), 67 HER2 type (9.6%), and 176 TNBC (25.1%). HER2 type showed the highest stromal GLS1 (P=0.001), tumoral GDH (P=0.001), stromal GDH (P
ISSN:	1351-0088 1479-6821
DOI:	10.1530/ERC-12-0398